Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
两次发生在洛杉矶的反抗时间之旅。两次对女人之间时而棘手的团结的赞颂。四位演员的精彩表演，来自吉塔娜·基基·罗德里格斯(Kitana Kiki Rodriguez)、米娅·泰勒(Mya Taylor)、茱莉亚·加纳，以及了不起的莉莉·汤姆林。《与外婆同行》是制片公司资深导演的作品，《橘色》是用iPhone手机拍摄。任何哀悼电影已死的人，都应该闭上嘴巴，看看这两部影片。
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Not until recently anyway. But scientists at Weill Cornell Medical College have at last managed to—at least with mice and monkeys. This produced artificial retinas, whose chips convert images into electronic signals and whose tiny projectors convert electronic signals into light.
Author Anthony Horowitz has revealed the new book Trigger Mortis has been amended for modern readers and contains anti-smoking messages and for the first time an ‘outspoken’ gay friend.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
As we ring in the New Year, let’s take stock of where we are at with the oil markets. 2014 proved to be a momentous one for the oil markets, having seen prices cut in half in just six months.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
"The only thing she's got is the woman card," Trump said. "I'd love to see a woman president, but she's the wrong person. She's a disaster."
Trends and targets in antiviral phototherapy
"I'm always amazed at how many people tell their co-workers about their job search," Kay says. "That's one of the worst things you can do." Ideally, you wouldn't tell any co-workers, but you may have to if you want them to serve as references. In that case, Kay says, "you need to pick people who you really trust, who don't have a hidden agenda and who won't let it slip."
“An employee packed up her belongings and walked out without a word.”
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Brazil's President Dilma Rousseff, who is facing impeachment, slashed her own salary by 10% to $103,400 a year last October as part of a wider austerity drive.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
The Portuguese school has risen 31 places over the past two years since its International Master in Management course was first included in the ranking.
Diagnostic technologies for COVID-19: a review
3.The Jungle Book
《一名拍摄黑手党的西西里摄影师和她的“鲜血档案”》(A Sicilian Photographer of the Mafia and Her ‘Archive of Blood’)
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
China's Ministry of Education (MOE) said at a news conference that most of the world's foreign students who study abroad are from China.
More than 100 countries are ranked according to 82 indicators of innovation, which is critical to driving growth in a competitive globalised world, said "The Global Innovation Index 2016". China's move up from 29th last year marks the first time a middle-income country has joined the top 25.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Inside larger technology companies, female employees will be hoping for signs of change in pay and promotions — but will also be on guard, as a men’s rights backlash brews in some corners of Silicon Valley.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
According to exam questions and some test-takers' feedback posted online after the exam, the difficulty of the questions was moderate and hot political and social issues, such as the Long March rockets, China's foreign affairs, the Yutu lunar rover and entrepreneurial efforts by college students, were mentioned.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Fund shareholders weren’t wasting any time reacting to this year of disappointment. Collectively, they’ve added just $35 billion to active stock-picking funds in the last 11 months, less than a quarter of the $162 billion they added in 2013, which was the first year of positive flows for the industry since 2007. This is not to say that they were sitting still. ETFs and passive index funds took in over $206 billion in net deposits through Thanksgiving, and Vanguard surpassed the $3 trillion mark sometime in late summer. Investors seem to have decided that they’d rather bet on the horses than the jockeys, after all.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
But closing the deal on RCEP less than a year after Donald Trump pulled the US out of the TPP would be a big win for Beijing.
Antiviral drug discovery: broad-spectrum drugs from nature
'If you read Trigger Mortis, you’ll see actually there is a little twist to the tale in that particular story which I think sort of pays him off for his slightly patronising attitude.'
Influenza neuraminidase: A druggable target for natural products
The French president would have ranked much higher had he not taken a 30% pay cut on assuming office in 2012.
13. iPhone 提醒
I'm going to disagree on one team you mentioned: the Kings. The West is a bit shallow again, and Sacramento is in the mix for a playoff spot. It's not likely or anything, but so long as they are in the mix, they have to pull out almost all the stops to grab it.
1. Battle of the Sexes
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
With a growing need for someone to block and tackle Apple’s raiders and (given its tax investigation in Europe) regulators, Mr Cook’s focus on people, strategy and execution — rather than products — finally started to look like an advantage.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The price of U.S. benchmark West Texas Intermediate crude, which is traded on the New York Mercantile Exchange, has been kept lower by problems transporting the oil to markets. Those troubles have eased recently, but Sabine Schels, head of fundamental commodity research at Bank of America Merrill Lynch, doubts the problems will disappear.
9. 《奎迪》(Creed)，导演：瑞恩·库格勒(Ryan Coogler)。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
3. Kraft. Brand love: -10% / Rank: 11
5.Celebrity Mocks Mao
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
At the same time, she said, other countries have seen their tourist numbers spike as the currencies weaken.
Inhibition of SARS coronavirus helicase by bismuth complexes
The country's improved performance has notched the 17th place in "innovation quality", an indicator that looks at the caliber of universities, number of scientific publications and international patent filings.
Gunal Youssouf, 23, is a Teach Firster who has joined the UK arm of PwC’s management consultancy graduate scheme. She says the two-year program-me gave her a chance to taste teaching without the cost of studying for a traditional qualification.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
伦敦商学院(London Business School，见上图)荣登2014年英国《金融时报》欧洲商学院排行榜榜首，该学院上一次夺得冠军宝座是在2005年。法国巴黎高等商学院(HEC Paris)和西班牙企业商学院(IE Business School)分列二、三位。
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
The Brexit trade uncertainty
Currency movements have had a strong impact on agricultural commodity prices this year, with the UK’s referendum on the EU leading to a sharp fall in the pound that pushed up the price of food imports and boosted agricultural exports.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Price is not everything, it is true. But even the bears would agree: everything has a price.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
A segment of Peking Opera from “Take Over The Weihu Mountain” (Yu Kuizhi and a student from Confucius Institute)
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Here's a full rundown of the activity—and inactivity—with an eye towards naming this year's trade deadline winners and losers.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Given that Dallas resisted tanking for years as Dirk Nowitzki's career has wound down and therefore has a fairly limited collection of young talent, adding the 22-year-old Noel without doing any major damage to its rotation counts as a smart play.
n. 能力，容量，容积; 资格，职位
“This could be just the beginning,” said Michael Na, a strategist in Seoul with Nomura.?“They have so many options to punish Korean businesses.”
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
One more scientific group, in Britain, that curates the world’s temperature record is scheduled to report in the coming weeks.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Tinashe featuring Devonté Hynes “Bet” (RCA)
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
“I am proud of my position as a boss, as a person that runs my own company,” Perry told FORBES for our Celebrity 100 cover story this past summer. “I’m an entrepreneur. … I don’t want to shy away from it. I actually want to kind of grab it by its b---s.”
Wishing you all the happiness of the holiday season.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
8) Let Me Think About That: Yeah, it sounds like a cop out. And it is…sometimes. Fact is, we don’t always have the authority or expertise to make decisions. This phrase buys you time and breathing space. Then, set a date and time for follow up so the other person knows you’re taking him serious.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
3．50 First Dates
The office predicts the number of football schools will increase to 20,000 this year and reach 50,000 by 2025.
A total of 61 IPOs were launched on the Shanghai and Shenzhen stock exchanges, down 67 percent on the same period last year. About 28.8 billion yuan (4.3 billion U.S.dollars) was raised, down by 80 percent.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
But Choupette isn't only a kept kitty, for she made more than ￡2.3million in one year alone after appearing in just two ad campaigns — one for Japenese beauty product Shu Uemura, and for German car company Vauxhall.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
2. David Virelles “Mbókò” (ECM) The brilliant young pianist David Virelles continues his interrogation of Afro-Cuban culture and ritual with methodical cool but also an openness of spirit. With Román Díaz thrumming a percussive heartbeat, this intoxicating suite resonates with implications both ancient and state-of-the-art.
具有荷兰和美国双重国籍的Frans de Waal和另一位美国科学家Jennifer Pokorny获得这一奖项，他们的研究确认黑猩猩可以通过辨认同类的屁股照片来认出不同的个体。
A modular microarray imaging system for highly specific COVID-19 antibody testing
Although Chinese domestic suppliers have expanded their market share to 32.7% in 2016, the trend was reversed in 2017, as their share shrank to 26.8%, said Qu Daokui, president of China Robot Industry Alliance.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
The official non-manufacturing PMI came in at 54.3 in October, down from a recent peak of 55.4 a month prior. A key sub-index for the services sector likewise fell 0.9 points from its September peak to 53.5. Even the construction industry appeared worse off, with a sub-index for the sector dropping 2.6 points to 58.5.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
In contrast, the average unit price of emerging market exports has been falling in year-on-year terms pretty much since mid-2012, hitting a year-on-year decline of 16.4 per cent in February 2016.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
泰勒·斯威夫特(Taylor Swift)，《空白空间》(Blank Space)， Big Machine
The data was released by the National Bureau of Statistics on its website, saying the growth rate rebounded for the first time after a four-year straight drop.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Recognize me?: image via blog.discoverymagazine.com
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Andy Murray's US Open victory and Olympic gold medal helped him to become the most searched-for British Olympian.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
8. 斯特吉尔·辛普森(Sturgill Simpson)，《乡村音乐的大现代之声》(Matamodern Sound in Country Music)，High Top Mountain。一支极为聪敏的乐队做出复古的改革：乡村乐中曾经发生过这样的事。但在斯特吉尔·辛普森突破性的第二张专辑中，他把这一点变成了可适应环境的标志，就建立在他那动人而通透的男中音之上。
15. 有趣的巧合。环球影业是题材最具多样性的制片公司之一，它发行了《生活残骸》，也发行了《冲出康普顿》，还有《泰迪熊2》(Ted 2)。环球影业的女导演也是最多的，12月初，它占据了今年24%的市场份额。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
I can well imagine that in 2016 the oil price will bounce back from its current sub $40 level. The Saudis may try to cut production, there could be more conflict in Iraq, terrorists could attack some of the prize targets such as the oil terminals at Ras Tanura and Abqaiq. Anything is possible, something is likely. But the question is how far the bounce will go.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
13. iPhone Reminders
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
“Someone resigned via a video conference call.”
Length-scale dependence of protein hydration-shell density
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Skeptics of climate change have long argued that global warming stopped around 1998, when an unusually powerful El Ni?o produced the hottest year of the 20th century. Some politicians in Washington have seized on that claim to justify inaction on emissions.
This quiet, intense Israeli film unfolds like a psychological thriller. A poetry-loving teacher discovers that one of her young pupils is a literary prodigy, and takes increasingly extreme measures to protect his gift from an indifferent world. As the story unfolds, it becomes clear that Mr. Lapid is engaged in a stealthy, ferocious critique of a society that has sacrificed its spiritual values and its cultural inheritance on the altar of power and materialism.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
8. Get Inspired
The US and European steel industries have accused China’s heavily subsidised sector of flooding the global market with steel, “dumping” it by selling below production costs and driving down international prices. The collapse in steel prices in recent years has caused the closure of mills across the world from Australia to the UK and parts of the US industrial heartland.
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